11385

Image

1 of 1

11385

Fluka

 

5-Azacytidine

BioChemika, ≥97.0% (HPLC)

Synonym:Ladakamycin, 4-Amino-1-(β-D-ribofuranosyl)-1,3,5-triazin-2(1H)-one
CAS Number:320-67-2
Linear Formula:C8H12N4O5
Molecular Weight:244.20
Beilstein Registry Number:620461
EC Number:206-280-2
MDL number:MFCD00006539

Description

ApplicationCancerostatic agent with weak antibiotic activity (gram-positive)
Biochem/physiol ActionsA potent growth inhibitor and cytotoxic agent; inhibits DNA methyltransferase, an important regulatory mechanism of gene expression, gene activation and silencing.

Properties

product lineBioChemika
assay≥97.0% (HPLC)
mp226-232 °C (dec.)(lit.)
storage temp.2-8°C

Safety

Personal Protective EquipmentEyeshields, Gloves, type P2 (EN 143) respirator cartridges
Hazard CodesT
Risk Statements45-46-22
Safety Statements53-22-36/37/39-45
WGK Germany3
RTECSXZ3017500

Related Products

Replaced byA2385, 5-Azacytidine

References

referenceKusaba H., et al., Association of 5′-CpG demethylation and altered chromatin structure in the promoter region with transcriptional activation of the multidrug resistance 1 gene in human cancer cells. Eur. J. Biochem. 262, 924-932, (1999)
 Broday L., et al., 5-Azacytidine induces transgene silencing by DNA methylation in Chinese hamster cells. Mol. Cell. Biol. 19, 3198-3204, (1999)
 Qian X., et al., DNA methylation regulates p27kip1 expression in rodent pituitary cell lines. Am. J. Pathol. 153, 1475-1482, (1998)
 Canova C., et al., Epigenetic control of programmed cell death: inhibition by 5-azacytidine of 1,25-dihydroxyvitamin D3-induced programmed cell death in C6.9 glioma cells. Mech. Ageing Dev. 101, 153-166, (1998)
MerckMerck 13,893
 Aldrich MSDS 1, 139:B / Corp MSDS 1 (1), 321:D / FT-IR 2 (3), 3896:C / FT-IR 1 (2), 831:D / FT-NMR 1 (3), 418:B / IR-Spectra (2), 1191:F / IR-Spectra (3), 1367:E / RegBook 1 (2), 2603:A / Sax 6, 332 / Sigma FT-IR 1 (1), 758:C / Structure Index 1, 411:B:5